Complex beauty complements membrane attack
نویسندگان
چکیده
منابع مشابه
Membrane Attack Complex in Systemic Lupus Erythematosus
Immune complexes localized in the kidneys of patients with systemic lupus erythematosus (SLE) 1 appear to play a central role in the pathogenesis of glomerulonephritis. Evidence supporting this hypothesis has been obtained from serial serologic studies (1-3), assay of specific antigen-antibody systems (4-7), measurement of serum immune complex levels (8-11), and immunocytochemical examination o...
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Complex systems and their underlying convoluted networks are ubiquitous, all we need is an eye for them. They pose problems of organized complexity which cannot be approached with a reductionist method. Complexity science and its emergent sister network science both come to grips with the inherent complexity of complex systems with an holistic strategy. The relevance of complexity, however, tra...
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We study spaces obtained from a complete finite volume complex hyperbolic n-manifold M by removing a compact totally geodesic complex (n−1)-submanifold S . The main result is that the fundamental group of M \S is relatively hyperbolic, relative to fundamental groups of the ends of M \S , and M \S admits a complete finite volume A -regular Riemannian metric of negative sectional curvature. It fo...
متن کاملStructural basis of complement membrane attack complex formation
In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a 'multi-hit' mechanism; however, sublytic MAC pores on host cells activate signalling pathways. Previous studies have described the structures of individual MAC components and subcomplexes; however, the molecular details of...
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PURPOSE To determine whether complement-derived SC5b-9, the soluble nonlytic-fluid phase of the membrane attack complex, can be generated in normal human corneas when they are injured with lipopolysaccharide (LPS), ribitol teichoic acid (RTA) immune complexes, acid, or alkali. METHODS The experimental cornea of each donor pair was injected with 50 microliters of sterile saline containing 0.5 ...
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ژورنال
عنوان ژورنال: Immunobiology
سال: 2016
ISSN: 0171-2985
DOI: 10.1016/j.imbio.2016.06.153